The synthesis of 5-hydroxymethyl-, 5-acetoxymethyl-, 5-formyl- and 5-cyanothieno(2,3-d)pyrimidines, the (methyl)-5-carboxylate, and the respective amide functionality was accomplished by building up the functionalized molecule starting from appropriately substituted thiophene precursors.A similar strategy starting from the pyrimidine precursor and subsequent direct functionalization.
Thioxothienopyrimidinones, alkylthio- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines a thienopyrimidinedione and a thienotriazolo.SYNTHESIS. Reviews and Full Papers in Chemical Synthesis. SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines.Structure, properties, spectra, suppliers and links for: thienopyrimidine, 272-68-4.
Identification of a thienopyrimidine derivatives target by a kinome and chemical biology approach. Lee C(1), Yang JS(1), Han G(2)(3). Author information: (1)Translational Research Center for Protein Function Control, Department of Biotechnology, Yonsei University, Seoul, 120-749, Republic of Korea.
Synthesis, Chemistry, and Biological Properties of Thienopyrimidines.
Lee, Chang Hoon; Lee, Kee-Jung: DABCO-Assisted Coupling of Some Activated Olefins and 2,3-Dihalo-1,4-naphthoquinones and Conversion to the Anthraquinone Derivatives.
A series of novel cycloalkylthieno(2,3- d )pyrimidinone derivatives have been conveniently synthesized via three steps including G-3CR, heterocyclization, and alkylation reactions as a part of our ongoing search for new bioactive molecules. The newly synthesized compounds were evaluated for their potential tumor cell growth inhibitory activity by standard MTT assay.
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Synthesis of 4-chloro-5,6-disubstitutedthieno(2,3-d)pyrimidine (4a-4c) 12-14 Compound 4a-c were synthesized by refluxing 0.01 mol of 2a for 3a, 2b for 3b, 2c for 3c, with 5 mL of POCl 3 for 3 hrs. POCl 3 was quenched by adding equal quantity of ice in respected solution and then extracted it with diethylether. 4-Chloro-6-methylthieno(2,3-d.
Novel thieno(2,3-d)pyrimidines containing a cyclohexane ring fused with a six- or five-membered heterocyclic moiety along with a benzylic nitrile were designed as potential inhibitors of PDE4.Expeditious synthesis of these compounds was carried out via a multi-step sequence consisting of a few key steps such as Gewald reaction, Dieckmann type cyclisation and Krapcho decarboxylation.
Domino synthesis of tetrasubstituted thiophenes from 1,3-enynes and mercaptoacetaldehyde using DABCO at room temperature offers broad substrate scope and mild reaction conditions. The reaction consists of a Michael addition, 5- exo -dig carboannulation, and oxidation sequence under air.
Multi-target ABC transporter modulators are of high (clinical) importance, not only due to their role in illnesses with high incidence in aging society (such as cancer-related MDR or Alzheimer's disease), or due to their huge impact on pharmacokinetics of drugs.
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The Progress Of 1,3,5-Triazine Derivatives As Anticancer Drug Abstract: Studies on the various types of cancer drugs is one of the important areas in clinical research. Identification and characterization of potential molecules from various sources have been carried out in the past and their relationship with the enzymes which are involved in cancer is becoming increasingly interesting.
Saeed Arayne M et al. Synthesis Characterization and Antimicrobial Activities of Azithromycin Metal Complexes. Mod Chem appl. 2014; 2: 133. Kerru N et al. Novel Thienopyrimidine Derivatives Containing 1,2,4-triazoles and 1,3,4-oxadiazoles as Potent Antimicrobial Activity. Med chem. 2014; 4: 623-629.
Synthesis of diverse heterocyclic scaffolds by using mixed oxides as heterogeneous catalysts. The Chemical Record. 300: Dr M.SURESH: Synthesis and antimicrobial activity of novel thienopyrimidine linked rhodanine derivatives. Canadian Journal of Chemistry. 301: Dr Aruna Polisetty.
Review - Free download as PDF File (.pdf), Text File (.txt) or read online for free. heterocyclic compounds.