Synthesis and antimicrobial activity of some new.

The synthesis of 5-hydroxymethyl-, 5-acetoxymethyl-, 5-formyl- and 5-cyanothieno(2,3-d)pyrimidines, the (methyl)-5-carboxylate, and the respective amide functionality was accomplished by building up the functionalized molecule starting from appropriately substituted thiophene precursors.A similar strategy starting from the pyrimidine precursor and subsequent direct functionalization.

Anticancer activity of some novel thieno (2, 3-d.

Thioxothienopyrimidinones, alkylthio- and arylalkylthiothienopyrimidinones, thienopyrimidinones, thienopyrimidines a thienopyrimidinedione and a thienotriazolo.SYNTHESIS. Reviews and Full Papers in Chemical Synthesis. SYNTHESIS is an international full-paper journal devoted to the advancement of the science of chemical synthesis. It covers all fields of organic chemistry involving synthesis, including catalysis, organometallic, medicinal, biological, and photochemistry, but also related disciplines.Structure, properties, spectra, suppliers and links for: thienopyrimidine, 272-68-4.


Data on the methods for the synthesis of isomeric thienopyrimidine derivatives, their chemical transformations, and biological activities are systematized and analyzed. Emphasis is given to studies published over the last 10—15 years.General Procedure for the synthesis of novel thienopyrimidine derivatives 9- 14. A mixture of ethyl 2-isothiocyanato-4, 5-dimethylthiophene-3- carboxylate 2 (2.41 g, 0.01 mole), sulfa-drugs (0.012 mole) in dimethylformamide (20 ml) containing 3 drops of triethylamine was heated under reflux for 14 h.

Thienopyrimidine Synthesis Essay

Identification of a thienopyrimidine derivatives target by a kinome and chemical biology approach. Lee C(1), Yang JS(1), Han G(2)(3). Author information: (1)Translational Research Center for Protein Function Control, Department of Biotechnology, Yonsei University, Seoul, 120-749, Republic of Korea.

Thienopyrimidine Synthesis Essay

Synthesis, Chemistry, and Biological Properties of Thienopyrimidines.

Thienopyrimidine Synthesis Essay

Lee, Chang Hoon; Lee, Kee-Jung: DABCO-Assisted Coupling of Some Activated Olefins and 2,3-Dihalo-1,4-naphthoquinones and Conversion to the Anthraquinone Derivatives.

Thienopyrimidine Synthesis Essay

A series of novel cycloalkylthieno(2,3- d )pyrimidinone derivatives have been conveniently synthesized via three steps including G-3CR, heterocyclization, and alkylation reactions as a part of our ongoing search for new bioactive molecules. The newly synthesized compounds were evaluated for their potential tumor cell growth inhibitory activity by standard MTT assay.

Thienopyrimidine Synthesis Essay

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Synthesis and antimicrobial activity of novel.

Thienopyrimidine Synthesis Essay

Synthesis of 4-chloro-5,6-disubstitutedthieno(2,3-d)pyrimidine (4a-4c) 12-14 Compound 4a-c were synthesized by refluxing 0.01 mol of 2a for 3a, 2b for 3b, 2c for 3c, with 5 mL of POCl 3 for 3 hrs. POCl 3 was quenched by adding equal quantity of ice in respected solution and then extracted it with diethylether. 4-Chloro-6-methylthieno(2,3-d.

Thienopyrimidine Synthesis Essay

Novel thieno(2,3-d)pyrimidines containing a cyclohexane ring fused with a six- or five-membered heterocyclic moiety along with a benzylic nitrile were designed as potential inhibitors of PDE4.Expeditious synthesis of these compounds was carried out via a multi-step sequence consisting of a few key steps such as Gewald reaction, Dieckmann type cyclisation and Krapcho decarboxylation.

Thienopyrimidine Synthesis Essay

Domino synthesis of tetrasubstituted thiophenes from 1,3-enynes and mercaptoacetaldehyde using DABCO at room temperature offers broad substrate scope and mild reaction conditions. The reaction consists of a Michael addition, 5- exo -dig carboannulation, and oxidation sequence under air.

Thienopyrimidine Synthesis Essay

Multi-target ABC transporter modulators are of high (clinical) importance, not only due to their role in illnesses with high incidence in aging society (such as cancer-related MDR or Alzheimer's disease), or due to their huge impact on pharmacokinetics of drugs.

Thienopyrimidine Synthesis Essay

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Design, Synthesis of Novel Thieno (2,3-d) derivatives and.

Thienopyrimidine Synthesis Essay

The Progress Of 1,3,5-Triazine Derivatives As Anticancer Drug Abstract: Studies on the various types of cancer drugs is one of the important areas in clinical research. Identification and characterization of potential molecules from various sources have been carried out in the past and their relationship with the enzymes which are involved in cancer is becoming increasingly interesting.

Thienopyrimidine Synthesis Essay

Saeed Arayne M et al. Synthesis Characterization and Antimicrobial Activities of Azithromycin Metal Complexes. Mod Chem appl. 2014; 2: 133. Kerru N et al. Novel Thienopyrimidine Derivatives Containing 1,2,4-triazoles and 1,3,4-oxadiazoles as Potent Antimicrobial Activity. Med chem. 2014; 4: 623-629.

Thienopyrimidine Synthesis Essay

Synthesis of diverse heterocyclic scaffolds by using mixed oxides as heterogeneous catalysts. The Chemical Record. 300: Dr M.SURESH: Synthesis and antimicrobial activity of novel thienopyrimidine linked rhodanine derivatives. Canadian Journal of Chemistry. 301: Dr Aruna Polisetty.

Thienopyrimidine Synthesis Essay

Review - Free download as PDF File (.pdf), Text File (.txt) or read online for free. heterocyclic compounds.

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